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Título: | Detection of anti-heat shock protein 90 β (Hsp90β) antibodies in cerebrospinal fluid |
Autor: | Cid, Cristina CSIC ORCID; García-Villanueva, M.; Salinas, Matilde; Alcázar, Alberto | Palabras clave: | Autoantibodies Cell membranes Cerebrospinal fluid Hsp90 Multiple sclerosis Western blot |
Fecha de publicación: | 10-ene-2007 | Editor: | Elsevier | Citación: | Journal of Immunological Methods 318(1-2): 153-157 (2007) | Resumen: | Antibodies against heat shock protein 90β (Hsp90β) recognize the antigen on the cell surface of the oligodendrocyte precursor cells and cause a decrease of oligodendrocyte population in cell cultures. These antibodies have been found in patients with multiple sclerosis (MS). This report describes an original and sensitive method to detect anti-Hsp90β antibodies in cerebrospinal fluid (CSF) using a western blot procedure. We have developed the method for autoantibody detection using Hsp90β from cell membrane fraction instead of commercial Hsp90β as antigen. The presence of anti-Hsp90β antibodies in CSF of MS patients may play a pathogenic role in MS, and a large-scale study is needed to establish a possible diagnostic value of these antibodies in MS patients. | Descripción: | 5 pages, 3 figures.-- PMID: 17112536 [PubMed].-- ISI Article Identifier: 000243858800017.-- Available online Oct 18, 2006. | Versión del editor: | http://dx.doi.org/10.1016/j.jim.2006.09.017 | URI: | http://hdl.handle.net/10261/13423 | DOI: | 10.1016/j.jim.2006.09.017 | ISSN: | 0022-1759 |
Aparece en las colecciones: | (CAB) Artículos |
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