Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/145719
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A cost for high levels of sperm competition in rodents: Increased sperm DNA fragmentation |
Autor: | Delbarco-Trillo, Javier CSIC ORCID; García-Álvarez, Olga CSIC ORCID; Soler, Ana J. CSIC ORCID; Tourmente, Maximiliano CSIC ORCID; Garde, José Julián CSIC ORCID; Roldán, Eduardo R. S. CSIC ORCID | Palabras clave: | Sperm competition Sperm chromatin structure assay Oxidative stress Capacitation Sperm DNA fragmentation Rodents |
Fecha de publicación: | 16-mar-2016 | Editor: | Royal Society (Great Britain) | Citación: | Proceedings of the Royal Society of London - B 283(1826): 20152708 (2016) | Resumen: | Spermcompetition, a prevalent evolutionary process inwhich the spermatozoa of two or more males compete for the fertilization of the same ovum, leads to morphological and physiological adaptations, including increases in energetic metabolism that may serve to propel sperm faster but that may have negative effects onDNA integrity. SpermDNA damage is associated with reduced rates of fertilization, embryo and fetal loss, offspring mortality, and mutations leading to genetic disease. We tested whether high levels of sperm competition affect sperm DNA integrity. We evaluated sperm DNA integrity in 18 species of rodents that differ in their levels of spermcompetition using the spermchromatin structure assay. DNA integrity was assessed upon sperm collection, in response to incubation under capacitating or non-capacitating conditions, and after exposure to physical and chemical stressors. Sperm DNA was very resistant to physical and chemical stressors, whereas incubation in noncapacitating and capacitating conditions resulted in only a small increase in spermDNA damage. Importantly, levels of spermcompetition were positively associated with sperm DNA fragmentation across rodent species. This is the first evidence showing that high levels of sperm competition lead to an important cost in the form of increased sperm DNA damage. | URI: | http://hdl.handle.net/10261/145719 | DOI: | 10.1098/rspb.2015.2708 | Identificadores: | doi: 10.1098/rspb.2015.2708 issn: 1471-2954 |
Referencias: | Delbarco-Trillo, Javier; García-Álvarez, Olga; Soler, Ana J.; Tourmente, Maximiliano; Garde, José Julián; Roldán, Eduardo R. S. (2016): Data from: A cost for high levels of sperm competition in rodents: increased sperm DNA fragmentation [Dataset]; Dryad; Version 1; https://doi.org/10.5061/dryad.cf2q1 |
Aparece en las colecciones: | (MNCN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Proc. R. Soc. B 283 20152708 2016.pdf | 378,03 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
8
checked on 10-abr-2024
SCOPUSTM
Citations
19
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
17
checked on 25-feb-2024
Page view(s)
296
checked on 18-abr-2024
Download(s)
212
checked on 18-abr-2024