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Título: | A Semaphorin 3A Inhibitor Blocks Axonal Chemorepulsion and Enhances Axon Regeneration |
Autor: | Montolio, Marisol; Messeguer, Joaquim CSIC; Masip, Isabel CSIC; Guijarro, Patricia; Gavin, Rosalina; Río, José Antonio del; Messeguer Peypoch, Ángel CSIC ORCID; Soriano, Eduardo | Palabras clave: | Semaphorin Axon guidance Semaphorin Induced Chemorepulsion Inhibitor (SICHI) Peripheral nervous system and central nervous system injury |
Fecha de publicación: | 16-jul-2009 | Editor: | Elsevier | Citación: | Chemistry and Biology (2009), doi: 10.1016/j.chembiol.2009.05.006 (In press) | Resumen: | Secreted semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance. We screened a peptoid combinatorial library to search for semaphorin 3A inhibitors, and identified a peptoid (SICHI: semaphorin Induced chemorepulsion inhibitor) that blocks semaphorin 3A-chemorepulsion and growth-cone collapse in axons at millimolar concentrations. SICHI inhibits the binding of semaphorin 3A to its receptor complex (neuropilin 1/plexin A1) and semaphorin 3A-induced phosphorylation of GSK3. Chemorepulsion induced by semaphorin 3F or netrin 1 is not blocked by SICHI. We also show that SICHI promotes neural regeneration of damaged axons. We suggest that SICHI, a selective inhibitor of semaphorin 3A, is of therapeutic interest for approaches aimed at promoting axonal regeneration and brain repair. | Descripción: | 11 pages, 7 figures.-- Article in press. Supporting information (Suppl. discussion, suppl. experimental procedures + suppl. fogis S1-S3, 5 pages) available at: http://dx.doi.org/10.1016/j.chembiol.2009.05.006 |
Versión del editor: | http://dx.doi.org/10.1016/j.chembiol.2009.05.006 | URI: | http://hdl.handle.net/10261/15090 | DOI: | 10.1016/j.chembiol.2009.05.006 | ISSN: | 1074-5521 |
Aparece en las colecciones: | (IQAC) Artículos |
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Semaphorin_Press_release.pdf | CSIC Press release (Spanish lang.) | 43,77 kB | Adobe PDF | Visualizar/Abrir |
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