Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/152722
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | New aspects on the regulation of the methionine cycle in liver injury |
Autor: | Pajares, María A. CSIC ORCID | Fecha de publicación: | 2015 | Citación: | 3rd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics (2015) | Resumen: | The methionine cycle produces S-adenosylmethionine (AdoMet) the main methyl donor for cellular transmethylations, including several epigenetic modifications. Alterations in this pathway and specifically in the AdoMet synthesis by methionine adenosyltransferases (MATs) have been reported in a large variety of diseases, although most studies have been performed in liver. The enzymes involved, excluding methyltransferases, are oligomers that were classically consider cytoplasmic. Thus, the AdoMet synthesized in the cytoplasm was expected to be transported to other compartments as required, a hypothesis further sustained by identification of an AdoMet mitochondrial transporter. However, in the last decade several reports have shown that this is not the case for the cell nucleus, where most of these enzymes have been identified in very low quantities. Work of my laboratory has recently provided evidences showing nuclear accumulation of several proteins of the methionine cycle in two models of acute liver injury. Moreover, we demonstrated that the nucleocytoplasmic distribution is governed by the ratio between glutathione species (GSH/GSSG). In fact, the oxidative stress induced by D-galactosamine or acetaminophen produces opposite effects on MAT I/III isoenzymes according to the subcellular compartment examined. This opposite regulation leads to decreased AdoMet production in the cytoplasm, whereas the nuclear levels of active MAT I increase, as well as certain epigenetic methylations. Prevention by N-acetylcysteine administration did not avoid all the drug-induced changes. Hence, we propose that alterations in the subcellular localization pattern of several enzymes of this cycle show a potential as biomarkers of liver disease. | Descripción: | Resumen del trabajo presentado a la 3rd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics, celebrada en valencia (España) del 1 al 3 de septiembre de 2015. | URI: | http://hdl.handle.net/10261/152722 |
Aparece en las colecciones: | (IIBM) Comunicaciones congresos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
131
checked on 18-mar-2024
Download(s)
39
checked on 18-mar-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.