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Título: | Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling |
Autor: | Cabrera, Jorge Rubén CSIC ORCID CVN; Sánchez-Pulido, Luis; Rojas Mendoza, Ana M. CSIC ORCID ; Valencia, Alfonso; Mañes, Santos; Naranjo, José Ramón CSIC ORCID; Mellström, Britt CSIC | Fecha de publicación: | 19-may-2006 | Editor: | American Society for Biochemistry and Molecular Biology | Citación: | Journal of Biological Chemistry 281(20): 14330-14339 (2006) | Resumen: | The growth arrest-specific gene 1 (Gas1) protein has been proposed to function during development as an inhibitor of growth and a mediator of cell death and is also re-expressed in adult neurons during excitotoxic insult. Here we have demonstrated that the Gas1 protein shows high structural similarity to the glial cell-derived neurotrophic factor (GDNF) family receptors α, which mediate GDNF responses through the receptor tyrosine kinase Ret. We found that Gas1 binds Ret in a ligand-independent manner and sequesters Ret in lipid rafts. Signaling downstream of Ret is thus modified through a mechanism that involves the adaptor protein Shc as well as ERK, eventually blocking Akt activation. Consequently, when Gas1 is induced, Ret-mediated GDNF-dependent survival effects are compromised. | Versión del editor: | http://doi.org/10.1074/jbc.M509572200 | URI: | http://hdl.handle.net/10261/153703 | DOI: | 10.1074/jbc.M509572200 | ISSN: | 0021-9258 | E-ISSN: | 1083-351X |
Aparece en las colecciones: | (CNB) Artículos |
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J. Biol. Chem.-2006-Cabrera-14330-9.pdf | 657,83 kB | Adobe PDF | Visualizar/Abrir |
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