Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/157643COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice |
Autor: | Li, Hongyun; Sánchez, Diego CSIC ORCID CVN; Ganfornina, M. D. CSIC ORCID CVN; Garner, Brett | Palabras clave: | Neurodegeneration Alzheimer's disease Amyloid pathology Amyloid β Apolipoprotein D |
Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Neurobiology of Aging 36(5): 1820-1833 (2015) | Resumen: | Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed. Here, we crossed both apoD-null mice and Thy-1 human apoD transgenic mice with APP-PS1 amyloidogenic AD mice. Loss of apoD resulted in a nearly 2-fold increase in hippocampal amyloid plaque load, as assessed by immunohistochemical staining. Conversely, transgenic expression of neuronal apoD reduced hippocampal plaque load by approximately 35%. This latter finding was associated with a 60% decrease in amyloid β 1-40 peptide levels, and a 34% decrease in insoluble amyloid β 1-42 peptide. Assessment of β-site amyloid precursor protein cleaving enzyme-1 (BACE1) levels and proteolytic products of amyloid precursor protein and neuregulin-1 point toward a possible association of altered BACE1 activity in association with altered apoD levels. In conclusion, the current studies provide clear evidence that apoD regulates amyloid plaque pathology in a mouse model of AD. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/157643 | DOI: | 10.1016/j.neurobiolaging.2015.02.010 | Identificadores: | doi: 10.1016/j.neurobiolaging.2015.02.010 e-issn: 1558-1497 issn: 0197-4580 |
| Aparece en las colecciones: | (IBGM) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
36
checked on 06-abr-2024
WEB OF SCIENCETM
Citations
35
checked on 22-feb-2024
Page view(s)
234
checked on 22-abr-2024
Download(s)
102
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.