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Título: | Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d] pyrimidin-7(6 H)-ones |
Autor: | Gómez-SanJuan, Asier CSIC; Gamo, Ana María CSIC; Delang, Leen; Pérez-Sánchez, Alfonso; Amrun, S. N.; Abdelnabi, Rana; Jacobs, S.; Priego, Eva María CSIC ORCID; Camarasa Rius, María José CSIC ORCID; Jochmans, D.; Leyssen, Pieter; Ng, L. F. P.; Querat, Guilles; Neyts, Johan; Peréz-Pérez, María-Jesús CSIC ORCID | Palabras clave: | Chikungunya virus Physicochemical properties Triazolopyrimidines |
Fecha de publicación: | 2018 | Editor: | American Chemical Society | Citación: | ACS Infectious Diseases 4: 605-619 (2018) | Resumen: | The re-emergence of chikungunya virus (CHIKV) is a serious global health threat. CHIKV is an alphavirus that is transmitted to humans by Aedes mosquitoes; therefore, their wide distribution significantly contributes to the globalization of the disease. Unfortunately, no effective antiviral drugs are available. We have identified a series of 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective inhibitors of CHIKV replication. New series of compounds have now been synthesized with the aim to improve their physicochemical properties and to potentiate the inhibitory activity against different CHIKV strains. Among these newly synthesized compounds modified at position 3 of the aryl ring, tetrahydropyranyl and N-t-butylpiperidine carboxamide derivatives have shown to elicit potent antiviral activity against different clinically relevant CHIKV isolates with 50% effective concentration (EC) values ranging from 0.30 to 4.5 μM in Vero cells, as well as anti-CHIKV activity in human skin fibroblasts (EC = 0.1 μM), a clinically relevant cell system for CHIKV infection. | Versión del editor: | http://dx.doi.org/10.1021/acsinfecdis.7b00219 | URI: | http://hdl.handle.net/10261/167013 | DOI: | 10.1021/acsinfecdis.7b00219 | Identificadores: | doi: 10.1021/acsinfecdis.7b00219 issn: 2373-8227 |
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ACS Infect Dis 2018.pdf | Artículo principal | 1,26 MB | Adobe PDF | Visualizar/Abrir |
Supp Info ACS Infect Dis.pdf | Supporting info | 603,72 kB | Adobe PDF | Visualizar/Abrir |
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