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| Título: | Middle East respiratory coronavirus accessory protein 4a inhibits PKR-mediated antiviral stress responses |
Autor: | Rabouw, Huib H.; Langereis, Martijn A.; Knaap, Robert C.; Dalebout, Tim J.; Cantón, Javier ; Solá Gurpegui, Isabel CSIC ORCID ; Enjuanes Sánchez, Luis CSIC ORCID ; Bredenbeek, Peter J.; Kikkert, Marjolein; Groot, Raoul J. de; Kuppeveld, Frank J. M. van | Fecha de publicación: | 26-oct-2016 | Editor: | Public Library of Science | Citación: | PLoS Pathogens 12(10): e1005982 (2016) | Resumen: | Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory infections that can be life-threatening. To establish an infection and spread, MERS-CoV, like most other viruses, must navigate through an intricate network of antiviral host responses. Besides the well-known type I interferon (IFN-alpha/beta) response, the protein kinase R (PKR)-mediated stress response is being recognized as an important innate response pathway. | Versión del editor: | http://dx.doi.org/10.1371/journal.ppat.1005982 | URI: | http://hdl.handle.net/10261/204075 | DOI: | 10.1371/journal.ppat.1005982 | Identificadores: | doi: 10.1371/journal.ppat.1005982 e-issn: 1553-7374 issn: 1553-7366 |
| Aparece en las colecciones: | (PTI Salud Global) Colección Especial COVID-19 (CNB) Artículos |
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| Middle East Respiratory Coronavirus.PDF | 4,34 MB | Adobe PDF |  Visualizar/Abrir |
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