Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/215762
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions |
Autor: | Risalde, María Ángeles CSIC ORCID; Roy, Álvaro; Bezos, Javier; Pineda, Carmen; Casal, Carmen; Díez-Guerrier, Alberto; Lopez-Villalba, Ignacio; Fernández-Manzano, Álvaro; Moreno, Inmaculada CSIC ORCID; Juan, Lucía de; Domínguez, Lucas CSIC; Gortázar, Christian CSIC ORCID | Fecha de publicación: | 2019 | Editor: | BMJ Publishing Group | Citación: | Veterinary Record 185(24): 759 (2019) | Resumen: | [Background]: There is evidence for a link between vitamin D deficiency and active tuberculosis (TB). In human beings, several trials have evaluated the role of vitamin D supplementation in TB treatment with conflicting results. However, the role of vitamin D supplementation in animal TB control has received less attention. The authors evaluated the benefit of vitamin D supplementation for preventing mycobacterial infection or reducing TB lesions (TBL) in a controlled trial with goats naturally exposed to Mycobacterium caprae. [Methods]: Two groups of goats, a vitamin D-supplemented group and a non-supplemented control group, were housed for 10 months in direct contact with M caprae-infected adult goats. Upon contact with the infected adult goats, all animals were TB-tested every two months. [Results]: No experimental evidence of a protective effect of vitamin D supplementation based on M caprae culture prevalence, TBL prevalence, median TBL score or the proportion of single versus multiple organs presenting TBL was observed. [Conclusion]: The results indicate that, in the conditions used in this study, vitamin D supplementation in goats does not reduce TB infection risk nor the diffusion and severity of TBL. In addition, vitamin D-supplemented goats presented hyperphosphataemia and renal injury with calcifications suggestive of vitamin D intoxication. | Versión del editor: | https://doi.org/10.1136/vr.105411 | URI: | http://hdl.handle.net/10261/215762 | DOI: | 10.1136/vr.105411 | Identificadores: | doi: 10.1136/vr.105411 issn: 0042-4900 e-issn: 2042-7670 |
Aparece en las colecciones: | (IREC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
122
checked on 18-abr-2024
Download(s)
23
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.