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Título: | Signalling and bioactive metabolites from Streptomyces sp. RK44 |
Autor: | Fang, Q.; Maglangit, F.; Wu, L.; Ebel, R.; Kyeremeh, K.; Andersen, J.H.; Annang, F.; Pérez-Moreno, Guiomar; Reyes, F.; Deng, H. | Palabras clave: | AHFA methylenomycin MMFs signalling molecules Streptomyces sp. RK44 Anticancer Antimalaria |
Fecha de publicación: | 2020 | Editor: | Molecular Diversity Preservation International | Citación: | Molecules 25 (2020) | Resumen: | Streptomyces remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of Streptomyces sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites from this strain resulted in the characterization of a new 2-alkyl-4-hydroxymethylfuran carboxamide (AHFA) 1 together with five known compounds, cyclo-(L-Pro-Gly) 2, cyclo-(L-Pro-L-Phe) 3, cyclo-(L-Pro-L-Val) 4, cyclo-(L-LeuHyp) 5, and deferoxamine E 6. AHFA 1, a methylenomycin (MMF) homolog, exhibited antiproliferative activity (EC50 = 89.6 µM) against melanoma A2058 cell lines. This activity, albeit weak is the first report amongst MMFs. Furthermore, the putative biosynthetic gene cluster (ahfa) was identified for the biosynthesis of AHFA 1. DFO-E 6 displayed potent anti-plasmodial activity (IC50 = 1.08µM) against P. falciparum 3D7. High-resolution electrospray ionization mass spectrometry (HR ESIMS) and molecular network assisted the targeted-isolation process, and tentatively identified six AHFA analogues, 7–12 and six siderophores 13–18. | Versión del editor: | http://dx.doi.org/10.3390/molecules25030460 | URI: | http://hdl.handle.net/10261/216684 | DOI: | 10.3390/molecules25030460 | Identificadores: | doi: 10.3390/molecules25030460 issn: 1420-3049 |
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