Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/218772
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells

AutorMarcelo, Gonçalo A.; Montpeyó, D.; Novio, Fernando CSIC ORCID; Ruiz Molina, Daniel CSIC ORCID; Lorenzo, Julia; Oliveira, Elisabete
Fecha de publicación2020
EditorElsevier
CitaciónDyes and Pigments 181: 108393 (2020)
ResumenNanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesised and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesised and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behaviour, with a pH 5.0 favouring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.
Versión del editorhttps://doi.org/10.1016/j.dyepig.2020.108393
URIhttp://hdl.handle.net/10261/218772
DOI10.1016/j.dyepig.2020.108393
ISSN0143-7208
Aparece en las colecciones: (CIN2) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
dyespigm_a2020v181n108393p-Pre.pdf1,01 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

9
checked on 17-mar-2024

WEB OF SCIENCETM
Citations

9
checked on 27-feb-2024

Page view(s)

126
checked on 27-mar-2024

Download(s)

38
checked on 27-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.