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Título: | Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells |
Autor: | Marcelo, Gonçalo A.; Montpeyó, D.; Novio, Fernando CSIC ORCID; Ruiz Molina, Daniel CSIC ORCID; Lorenzo, Julia; Oliveira, Elisabete | Fecha de publicación: | 2020 | Editor: | Elsevier | Citación: | Dyes and Pigments 181: 108393 (2020) | Resumen: | Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesised and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesised and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behaviour, with a pH 5.0 favouring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent. | Versión del editor: | https://doi.org/10.1016/j.dyepig.2020.108393 | URI: | http://hdl.handle.net/10261/218772 | DOI: | 10.1016/j.dyepig.2020.108393 | ISSN: | 0143-7208 |
Aparece en las colecciones: | (CIN2) Artículos |
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