Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/219120
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Sonochemical synthesis of polyoxometalatestabilized gold nanoparticles for point-of-care determination of acetaminophen levels: preclinical study in an animal model

AutorRohani Bastami, Tahereh; Ghaedi, Abolphazl; Mitchell, Scott G. CSIC ORCID; Javadian-Saraf, Aida; Karimi, Mohammad
Fecha de publicación2020
EditorRoyal Society of Chemistry (UK)
CitaciónRSC Advances 10(28): 16805-16816 (2020)
ResumenThe aim of this study is the accurate and rapid detection of acetaminophen (AP) for point-of-care (POC) clinical diagnosis. Acetaminophen overdose causes acute liver failure and currently there is a lack of rapid quantitative detection methods for this drug in the emergency room. Here, low-frequency sonication (20 kHz) in the presence of phosphomolybdic acid (PMo12) was used to reduce Au3+ to Au0 and stabilize the resulting spherical Au0 nanoparticles (herein AuNPs). These AuNPs@PMo12 were used as nano-probes for the selective detection of acetaminophen in the presence of other commercial drugs. The optical sensing method we describe is based on the aggregation of AuNPs@PMo12 in the presence of acetaminophen, which produces a red-shift in the absorption spectrum of the AuNPs@PMo12, which is characterised by a color change from red to purple that is visible to the naked eye. Furthermore, the quantitative determination of acetaminophen concentrations can be carried out using the eyedropper function in Microsoft's PowerPoint or open access ImageJ software, using RGB (red, green, and blue) values. To prove the feasibility of this novel nanosensor, the concentration of acetaminophen was measured in over-the-counter pharmaceutical tablets and in serum samples taken from mice. This simple sensing approach offers high stability, selectivity, rapid detection time, and cost saving compared to other detection methods, which therefore opens the way for the development of quantitative POC acetaminophen detection using polyoxometalate-stabilized metal nanoparticles.
Versión del editorhttps://doi.org/10.1039/D0RA00931H
URIhttp://hdl.handle.net/10261/219120
DOI10.1039/D0RA00931H
E-ISSN2046-2069
Aparece en las colecciones: (ICMA) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
sonochemodel.pdf2,76 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

WEB OF SCIENCETM
Citations

17
checked on 22-feb-2024

Page view(s)

133
checked on 29-mar-2024

Download(s)

169
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Este item está licenciado bajo una Licencia Creative Commons Creative Commons