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Título: | Advances in enzymatic oxyfunctionalization of aliphatic compounds |
Autor: | Aranda, Carmen CSIC; Carro, Juan ; González-Benjumea, Alejandro CSIC ORCID; Babot, Esteban Daniel CSIC ORCID; Olmedo, Andrés CSIC ORCID; Linde, Dolores CSIC ORCID ; Martínez, Ángel T. CSIC ORCID ; Gutiérrez Suárez, Ana CSIC ORCID | Palabras clave: | Alkanes Biocatalysis Epoxidation Fatty acids Hydroxylation Oxyfunctionalization Peroxygenases Terpenoids UPO P450 |
Fecha de publicación: | 3-feb-2021 | Editor: | Elsevier | Citación: | Biotechnology Advances 107703 (2021) Article in press | Resumen: | Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as “dream biocatalysts” of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. © 2021 The Authors | Descripción: | 19 páginas.- 8 figuras.- 5 tablas.- 174 referencias | Versión del editor: | http://dx.doi.org/10.1016/j.biotechadv.2021.107703 | URI: | http://hdl.handle.net/10261/236621 | DOI: | 10.1016/j.biotechadv.2021.107703 | ISSN: | 0734-9750 |
Aparece en las colecciones: | (IRNAS) Artículos (CIB) Artículos |
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Biotechnology Advances_107703_(2021).pdf | 7,64 MB | Adobe PDF | Visualizar/Abrir |
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