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Título: | The Journey of Human Drugs from Their Design at the Bench to Their Fate in Crops |
Autor: | Montemurro, Nicola CSIC ORCID CVN; Peña-Herrera, Juan Manuel CSIC ORCID; Ginebreda Martí, Antoni CSIC ORCID; Eichhorn, Peter; Pérez, Sandra | Palabras clave: | ADME Analytical methods Crops Distribution Drug development Drug discovery Earthworms Fate Humans Metabolism Soil Wetlands |
Fecha de publicación: | 21-ago-2020 | Editor: | Springer Nature | Citación: | Interaction and Fate of Pharmaceuticals in Soil-Crop Systems 3-31 (2020) | Resumen: | The topic of this book is dedicated to the analysis, fate, metabolism, effects, and remediation of pharmaceutically active compounds in water-soil-biota systems. While the majority of readers are likely to already have a broad understanding of potential entry points, flows, transformation pathways, and temporary and permanent sinks of drugs in the environment, the objectives of this first chapter are fourfold: (a) to provide a concise overview of the journey a drug takes from its inception at the laboratory bench to the desk of the reviewer at the regulatory agency; (b) to understand the biological and physiological processes a drug undergoes from administration to humans – or to the animal in case of veterinary medicines – to their excretion and ultimately discharge into wastes; (c) to describe the physico-chemical space small-molecule drugs reside in as this characteristic largely governs their later environmental fate; (d) to review their presence, fate, and metabolism in crops and plants determined using innovative analytical methods; as well as (e) to evaluate the effects and remediation of drugs in crops and biota. | Versión del editor: | https://doi.org/10.1007/698_2020_643 | URI: | http://hdl.handle.net/10261/237337 | DOI: | 10.1007/698_2020_643 |
Aparece en las colecciones: | (IDAEA) Libros y partes de libros |
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Chapter_643 NM.pdf | Capítulo de libro | 543,76 kB | Adobe PDF | Visualizar/Abrir |
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