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Título: | Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in mice |
Autor: | Lázaro-Frías, Adrián; Pérez Ramírez, Patricia CSIC ORCID ; Zamora, Carmen; Sánchez-Cordón, P. J.; Guzmán, María; Luczkowiak, Joanna; Delgado, Rafael; Casasnovas, José María CSIC ORCID ; Esteban, Mariano CSIC ORCID ; García-Arriaza, Juan CSIC ORCID | Fecha de publicación: | 9-feb-2022 | Editor: | Nature Publishing Group | Citación: | NPJ Vaccines 7(1): 17 (2022) | Resumen: | Two doses of the MVA-CoV2-S vaccine candidate expressing the SARS-CoV-2 spike (S) protein protected K18-hACE2 transgenic mice from a lethal dose of SARS-CoV-2. This vaccination regimen prevented virus replication in the lungs, reduced lung pathology, and diminished levels of pro-inflammatory cytokines. High titers of IgG antibodies against S and receptor-binding domain (RBD) proteins and of neutralizing antibodies were induced against parental virus and variants of concern, markers that correlated with protection. Similar SARS-CoV-2-specific antibody responses were observed at prechallenge and postchallenge in the two-dose regimen, while the single-dose treatment does not avoid vaccine breakthrough infection. All vaccinated animals survived infection and were also protected to SARS-CoV-2 reinfection. Furthermore, two MVA-CoV2-S doses induced long-term memory S-specific humoral and cellular immune responses in C57BL/6 mice, 6 months after immunization. The efficacy and immunological benefits of the MVA-CoV2-S vaccine candidate against COVID-19 supports its consideration for human clinical trials. | Versión del editor: | https://doi.org/10.1038/s41541-022-00440-w | URI: | http://hdl.handle.net/10261/264372 | DOI: | 10.1038/s41541-022-00440-w | E-ISSN: | 2059-0105 |
Aparece en las colecciones: | (INIA) Artículos (PTI Salud Global) Colección Especial COVID-19 (CNB) Artículos |
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