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| Título: | PAP1 signaling involves MAPK signal transduction |
Autor: | Ferrés-Masó, Montse CSIC; Iovanna, Juan Lucio; Closa, Daniel CSIC ORCID; Folch-Puy, Emma CSIC ORCID | Palabras clave: | PAP1 MAPK Transcriptional factors AR42J Chromatin immunoprecipitation RNApol ChIP |
Fecha de publicación: | 12-may-2009 | Editor: | Springer Nature | Citación: | Cellular and Molecular Life Sciences 66(13): 2195-2204 (2009) | Resumen: | Pancreatitis-associated protein 1 (PAP1) belongs to the Reg family of secretory proteins. Several important biological roles have been attributed to PAP1 but the signaling pathways activated by this protein remain only partially understood. Here, we describe the intracellular pathways triggered by PAP1 in a pancreatic acinar cell line. Taking advantage of the fact that PAP1 induces its own transcription, we performed ChIP assays to analyze the recruitment of transcriptional factors on its promoter. Our results show that PAP1 increased the transactivation activity of pap1 and the binding on its promoter of the nuclear factors C/EBPβ, P-CREB, P-ELK1, EGR1, STAT3, and ETS2, which are downstream targets of MAPK signaling. p44/42, p38, and JNK MAPKs activity increased after PAP1 treatment. In addition, pharmacological inhibition of these kinases markedly inhibited the induction of pap1 mRNA. Taken together, these results indicated that the mechanism of PAP1 action involves the activation of the MAPK superfamily. | Descripción: | El pdf del artículo es la versión post-print.-- et al. | Versión del editor: | http://dx.doi.org/10.1007/s00018-009-0040-4 | URI: | http://hdl.handle.net/10261/33336 | DOI: | 10.1007/s00018-009-0040-4 | ISSN: | 1420-682X | E-ISSN: | 1420-9071 |
| Aparece en las colecciones: | (IIBB) Artículos |
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| PAP1 signaling involves.pdf | 807,37 kB | Adobe PDF |  Visualizar/Abrir |
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