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Título: | Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition |
Autor: | Blanco-Aparicio, Carmen; García Collazo, Ana María; Oyarzabal, Julen; Leal, Juan F. M.; Albarrán, María Isabel; Ramos Lima, Francisco; Pequeño, Belén; Ajenjo, Nuria; Becerra, Mercedes; Alfonso, Patricia; Reymundo, María Isabel; Palacios, Irene CSIC; Mateos, Genoveva; Quiñones, Helena; Corrionero, Ana; Carnero, Amancio CSIC ORCID; Pevarello, Paolo; Rodríguez López, Ana CSIC ORCID; Fominaya, Jesús; Pastor, Joaquín; Bischoff, James R. | Palabras clave: | Pim 1 Kinase inhibitors PI3K AML |
Fecha de publicación: | 3-nov-2010 | Editor: | Elsevier | Citación: | Cancer Letters 300(2): 145-153 (2011) | Resumen: | The serine/threonine Pim 1 kinase is an oncogene whose expression is deregulated in several human cancers. Overexpression of Pim 1 facilitates cell cycle progression and suppresses apoptosis. Hence pharmacologic inhibitors of Pim 1 are of therapeutic interest for cancer. ETP-45299 is a potent and selective inhibitor of Pim 1 that inhibits the phosphorylation of Bad and 4EBP1 in cells and suppresses the proliferation of several non-solid and solid human tumor cell lines. The combination of the PI3K inhibitor GDC-0941 with ETP-45299 was strongly synergistic in MV-4-11 AML cells, indicating that the combination of selective Pim kinase inhibitors and PI3K inhibitor could have clinical benefit. | Descripción: | 9 páginas, 4 figuras, 2 tablas. | Versión del editor: | http://dx.doi.org/10.1016/j.canlet.2010.09.016 | URI: | http://hdl.handle.net/10261/38835 | DOI: | 10.1016/j.canlet.2010.09.016 | ISSN: | 0304-3835 |
Aparece en las colecciones: | (IBIS) Artículos |
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