Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/48680
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Genome-wide screening of genes whose enhanced expression affects glycogen accumulation in escherichia coli |
Autor: | Eydallin, Gustavo CSIC; Montero, Manuel CSIC ORCID; Almagro, Goizeder CSIC ORCID ; Sesma, María Teresa CSIC; Viale, Alejandro M. CSIC; Muñoz Pérez, Francisco José CSIC ORCID ; Rahimpour, Mehdi CSIC; Baroja-Fernández, Edurne CSIC ORCID CVN ; Pozueta Romero, Javier CSIC ORCID | Palabras clave: | ASKA library Carbohydrate metabolism Functional genomics |
Fecha de publicación: | abr-2010 | Editor: | Oxford University Press | Citación: | DNA Research 17(2): 61-71 (2010) | Resumen: | Using a systematic and comprehensive gene expression library (the ASKA library), we have carried out a genome-wide screening of the genes whose increased plasmid-directed expression affected glycogen metabolism in Escherichia coli. Of the 4123 clones of the collection, 28 displayed a glycogen-excess phenotype, whereas 58 displayed a glycogen-deficient phenotype. The genes whose enhanced expression affected glycogen accumulation were classified into various functional categories including carbon sensing, transport and metabolism, general stress and stringent responses, factors determining intercellular communication, aggregative and social behaviour, nitrogen metabolism and energy status. Noteworthy, one-third of them were genes about which little or nothing is known. We propose an integrated metabolic model wherein E. coli glycogen metabolism is highly interconnected with a wide variety of cellular processes and is tightly adjusted to the nutritional and energetic status of the cell. Furthermore, we provide clues about possible biological roles of genes of still unknown functions. | Descripción: | 11 p., 3 figures, 2 tables and bibliography | Versión del editor: | http://dx.doi.org/10.1093/dnares/dsp028 | URI: | http://hdl.handle.net/10261/48680 | DOI: | 10.1093/dnares/dsp028 | ISSN: | 1340-2838 | E-ISSN: | 1756-1663 |
Aparece en las colecciones: | (IDAB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Genome-wide-screening-of-genes-whose-enhanced-expression.pdf | 311,52 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
20
checked on 22-mar-2024
SCOPUSTM
Citations
36
checked on 21-mar-2024
WEB OF SCIENCETM
Citations
34
checked on 23-feb-2024
Page view(s)
408
checked on 28-mar-2024
Download(s)
283
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.