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Título: | Actions of estrogens on glial cells: Implications for neuroprotection |
Autor: | Arévalo, María Ángeles CSIC ORCID ; Santos-Galindo, María CSIC ORCID; Bellini, María José CSIC ORCID; Azcoitia, I.; García-Segura, Luis M. CSIC ORCID | Fecha de publicación: | 2010 | Editor: | Elsevier | Citación: | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1800: 1106- 1112 (2010) | Resumen: | Glial cells are directly or indirectly affected by estradiol and by different estrogenic compounds, such as selective estrogen receptor modulators. Acting on oligodendrocytes, astrocytes and microglia, estrogens regulate remyelination, edema formation, extracellular glutamate levels and the inflammatory response after brain injury. In addition, estradiol induces the expression and release of growth factors by glial cells that promote neuronal survival. Therefore, glial cells are important players in the neuroprotective and reparative mechanisms of estrogenic compounds. © 2009 Elsevier B.V. | URI: | http://hdl.handle.net/10261/59581 | DOI: | 10.1016/j.bbagen.2009.10.002 | Identificadores: | doi: 10.1016/j.bbagen.2009.10.002 issn: 0304-4165 |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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