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Título: | Molecular characterization and central distribution of the estradiol receptor alpha (ERα) in the sea bass (Dicentrarchus labrax) |
Autor: | Muriach, Borja CSIC; Cerdá-Reverter, José Miguel CSIC ORCID CVN ; Gómez, Ana CSIC ORCID; Zanuy, Silvia CSIC ORCID ; Carrillo, Manuel CSIC ORCID | Fecha de publicación: | 2008 | Editor: | Elsevier | Citación: | Journal of Chemical Neuroanatomy 35(1): 33-48 (2008) | Resumen: | Three different estrogen receptors (ERs) have been cloned and characterized in teleosts fish, i.e. ERα, ERβ or ERβ1 and ERγ or ERβ2. In order to study the sea bass ER subtype involved in the regulation of gonadotropin production, as well as to elucidate the possible involved neuronal pathways, we characterized the transactivation properties of the cloned sea bass ERα (sbERα) and studied its distribution in the brain and gonadotropic cells of the sea bass by in situ hybridization. The results revealed that sbERα transactivates promoters containing estradiol responsive elements (ERE) in a dose-response manner. The sbERα showed the highest affinity for 17-β-estradiol. In situ hybridization studies demonstrated that ERα mRNA positive neurons are widely distributed within the sea bass brain, including the telencephalon, preoptic area, thalamus, hypothalamus, mesencephalic tectum and tegmentum and rhombencephalon. New estrogen dependent nuclei were described in all above areas. The sbERα was profusely expressed in the main neuroendocrine areas such as the preoptic area and hypothalamus, thus suggesting the steroidal modulation of the hypophysiotropic neurons. The presence of sbERα expression in the FSHβ and LHβ cells suggests a direct effect of estrogens in the control of gonadotropin hormone synthesis. | URI: | http://hdl.handle.net/10261/72058 | DOI: | 10.1016/j.jchemneu.2007.05.010 | Identificadores: | doi: 10.1016/j.jchemneu.2007.05.010 issn: 0891-0618 |
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