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Título: | Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
Autor: | Polledo, Laura CSIC ORCID; González, J.; Benavides, Julio CSIC ORCID ; Morales, S.; Martínez-Fernández, B.; Delgado, L. CSIC; Reina, Ramsés CSIC ORCID ; Glaria, Idoia CSIC ORCID ; Pérez Pérez, Valentín CSIC ORCID ; Pérez Pérez, Valentín CSIC ORCID ; Ferreras, Mª del Carmen CSIC ORCID ; García Marín, Juan Francisco CSIC | Palabras clave: | Immunopathology Lentivirus Maedi-visna Sheep |
Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | Journal of Comparative Pathology 147(1): 1-10 (2012) | Resumen: | This study investigates the nervous form of ovine maedi-visna by histological and immunohistochemical techniques. The aim was to study the lesion types and the local cellular immune response related to each lesion type, and the possible relationship between these parameters. Thirty-four Assaf ewes were studied, 29 of which had shown nervous signs. Microscopical lesion patterns were described according to location, extent and predominance of inflammatory cell type. Immunohistochemical labelling of T cells (CD3(+), CD4(+), CD8(+) and cells expressing the gamma delta form of the T-cell receptor), B cells and macrophages revealed clear differences between the lesion patterns. Two main lesion types were described. Lymphocytic lesions had areas of mild-moderate injury characterized by a predominance of infiltrating T cells. Histiocytic lesions were more severe and had extensive areas of malacia and dominant infiltration by macrophages and B cells. Each animal had a unique lesion pattern and these differences could be due to individual resistance to the progression of infection. The lymphocytic lesions appear to represent initial or latent phases of slow progression, in which the animal presents some natural resistance to the infection. The histiocytic pattern may reflect a poor immune response or a greater virulence of the viral strain. | Descripción: | 10 páginas. | Versión del editor: | http://dx.doi.org/10.1016/j.jcpa.2011.09.003 | URI: | http://hdl.handle.net/10261/73100 | DOI: | 10.1016/j.jcpa.2011.09.003 | ISSN: | 0021-9975 |
Aparece en las colecciones: | (IGM) Artículos (IDAB) Artículos |
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