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Título: | Role of an atypical E2F transcription factor in the control of arabidopsis cell growth and differentiation |
Autor: | Ramírez-Parra, Elena CSIC ORCID ; López-Matas, M. Ángeles; Fründt, Corinne; Gutiérrez Armenta, Crisanto CSIC ORCID | Palabras clave: | Arabidopsis thaliana E2Ff Plants |
Fecha de publicación: | 12-ago-2004 | Editor: | American Society of Plant Biologists | Citación: | The Plant Cell 16:2350-2363 (2004) | Resumen: | The balance between cell proliferation and differentiation is crucial in multicellular organisms, where it is regulated by complex gene expression networks. This is particularly relevant in plants because organogenesis is a continuous postembryonic process. Here, we investigate the function of Arabidopsis thaliana E2Ff, an atypical member of the E2F family of transcription factors, which acts independently of a dimerization partner. We have focused our analysis on roots and hypocotyls, organs where (1) cell proliferation and differentiation are spatially and/or temporally separated, (2) growth depends on cell expansion in the longitudinal axis, and (3) the AtE2Ff promoter is active. AtE2Ff overexpression produced a reduction in the size of differentiated cells of these organs. Cells of mutant e2ff-1 plants with reduced levels of AtE2Ff mRNA were larger, especially in the hypocotyl, suggesting a role as a growth regulator. These effects of AtE2Ff are not associated with changes in nuclear ploidy levels or in the expression of cell cycle marker genes. However, expression of a subset of cell wall biogenesis genes is misregulated in an AtE2Ff-dependent manner, and based on chromatin immunoprecipitation experiments, they seem to be direct E2F targets. Our results highlight the complex regulatory function exerted by E2F and suggest a possible role of AtE2Ff in repressing cell wall biosynthesis genes during cell elongation in differentiated cells | Versión del editor: | http://dx.doi.org/10.1105/tpc.104.023978 | URI: | http://hdl.handle.net/10261/8245 | DOI: | 10.1105/tpc.104.023978 | ISSN: | 1040-4651 | E-ISSN: | 1532-298X |
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