Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/82895
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Concentration-dependent effects of titanium and aluminium ions released from thermally oxidized Ti6Al4V alloy on human osteoblasts |
Autor: | Saldaña, L.; Barranco, Violeta CSIC ORCID ; García-Alonso, M. C. CSIC ORCID ; Vallés, G.; Escudero Rincón, María Lorenza; Munuera, L.; Vilaboa, N. | Palabras clave: | Oxidation Thermal oxidation Osteoblast |
Fecha de publicación: | 2006 | Editor: | Wiley-VCH | Citación: | Journal of Biomedical Materials Research - Part A 77: 220-229 (2006) | Resumen: | Thermal oxidation treatments of Ti6Al4V, at 500 and 700°C, for 1 h result in the formation of an outer "ceramic" layer of rutile, which enhances osteoblast response. In the present study, we have measured in vitro Ti and Al ion release from Ti64 alloy in the as-received state and after thermal oxidation treatments at 500 or 700°C, to culture medium under standard cell-culture conditions. Concentrations of both Ti and Al released from both thermal oxidation treatments were lower than from polished alloy. Al was released from the treated or untreated surfaces in substantially lower extent than Ti. Titanium and aluminium ions affected primary human osteoblast proliferation, metabolic activity, and differentiation in a dose-dependent manner. Treatments with individual Ti or Al metal ions in similar concentration ranges than released from the surfaces did not alter osteoblast response, which also remained unaffected after treatments with combinations of Ti plus Al applied in the proportional relations than detected in ion-release experiments. We then selected higher concentrations of Ti that impaired osteoblast proliferation and differentiation, while the proportional lower concentrations of Al did not alter osteoblast behavior. In spite of its inert character, it was found that Al significantly enhanced the deleterious effect of Ti on osteoblast differentiation. Therefore, thermal oxidation treatments of Ti6Al4V alloy may improve the biocompatibility of the alloy by reducing both Ti and Al release, and thus attenuating ion-mediated interference with osteoblast differentiation. © 2005 Wiley Periodicals, Inc. | Versión del editor: | http://dx.doi.org/10.1002/jbm.a.30599 | URI: | http://hdl.handle.net/10261/82895 | DOI: | 10.1002/jbm.a.30599 | ISSN: | 1549-3296 |
Aparece en las colecciones: | (CENIM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Embargo_Gral.pdf | 21,67 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
32
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
28
checked on 24-feb-2024
Page view(s)
359
checked on 19-abr-2024
Download(s)
323
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.