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Título: | RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions |
Autor: | Cruz-Gallardo, Isabel CSIC ORCID; Aroca, Ángeles CSIC ORCID; Persson, Cecilia; Karlsson, B. Göran; Díaz-Moreno, Irene CSIC ORCID | Palabras clave: | DNA/RNA binding protein (D/RBP) pH-dependence NMR RNA recognition motif (RRM) T-cell intracellular antigen-1 (TIA-1) |
Fecha de publicación: | 2013 | Editor: | American Society for Biochemistry and Molecular Biology | Citación: | Journal of Biological Chemistry, (2013) | Resumen: | Background: T-cell intracellular antigen- 1(TIA-1) is a key DNA/RNA binding protein in RNA metabolism. Results: The binding of TIA-1 RRM3 domain (isolated or fused to RRM2) to RNA is affected by pH changes. Conclusion: The pH-dependence of RRM3/RNA interaction may have a significant effect in the overall TIA-1 function. Significance: Unveiling the auxiliary role of RRM3 in RNA recognition sheds light on the TIA-1 function between cell compartments changes due to the protonation / deprotonation of TIA-1 RRM3 histidine residues. The auxiliary role of the Cterminal RRM3 domain in TIA-1 RNA recognition is poorly understood and this work provides an insight into its binding mechanisms | Versión del editor: | http://dx.doi.org/10.1074/jbc.M113.489070 | URI: | http://hdl.handle.net/10261/95466 | DOI: | 10.1074/jbc.M113.489070 |
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J. Biol. Chem.-2013-Cruz-Gallardo-jbc.M113.489070.pdf | 3,61 MB | Adobe PDF | Visualizar/Abrir |
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