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Título: | Biofilm switch and immune response determinants at early stages of infection |
Autor: | Valle Turrillas, Jaione CSIC ORCID; Solano Goñi, Cristina CSIC ORCID; García, Begoña CSIC ORCID; Toledo-Arana, Alejandro CSIC ORCID ; Lasa, Íñigo CSIC ORCID | Palabras clave: | Innate immune response Chronic infection Biofilms c-di-GMP STING cGAS PAMPsType I interferon |
Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | Trends in Microbiology 21(8): 364-371 (2013) | Resumen: | Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development. © 2013 Elsevier Ltd. | URI: | http://hdl.handle.net/10261/97197 | DOI: | 10.1016/j.tim.2013.05.008 | Identificadores: | doi: 10.1016/j.tim.2013.05.008 issn: 0966-842X e-issn: 1878-4380 |
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