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Título: | Casein modified gold nanoparticles for future theranostic applications |
Autor: | Espinoza-Castañeda, Marisol CSIC; Escosura-Muñiz, Alfredo de la CSIC ORCID; Merkoçi, Arben CSIC ORCID | Palabras clave: | Hydrogen evolution electrocatalysis Theranostic Caseinglycomacropeptide Caseinglycopeptide Bacteria Gold nanoparticle Biosensors |
Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | Biosensors and Bioelectronics 40(1): 271-276 (2013) | Resumen: | The synthesis and characterization of gold nanoparticles (AuNPs 20. nm sized) modified with k-casein derived peptides in order to monitor the peptide effect as bacterial adhesion inhibitor, thanks to the carrier/concentrator effect of the AuNPs is here presented. Some aspects related to the stability of AuNP/peptide conjugates for a potential application in the design of an electrochemical biosensor for pathogen bacteria detection are also discussed. This peptide based nanoparticle assay takes advantage of the dual character of the AuNPs: as carrier of the biorecognition molecule and also as electrocatalytic label, allowing the evaluation of the pathogen bacteria-peptide interaction in a simple and rapid way through the chronoamperometric monitoring of the hydrogen evolution reaction on screen-printed carbon electrodes. The developed proof of concept theranostic system may open the way to therapeutic and biosensing applications with interest for various fields. © 2012 Elsevier B.V. | URI: | http://hdl.handle.net/10261/99203 | DOI: | 10.1016/j.bios.2012.07.042 | Identificadores: | doi: 10.1016/j.bios.2012.07.042 issn: 0956-5663 e-issn: 1873-4235 |
Aparece en las colecciones: | (CIN2) Artículos |
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