Risk model for colorectal cancer in Spanish population using environmental and genetic factors : results from the MCC-Spain study
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Autoría
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Fecha de publicación
2017 -
Editorial
Nature Publishing Group -
Cita bibliográfica
Ibáñez Sanz, G., Alguacil Ojeda, J., Moreno, V.... [et al.]: "Risk model for colorectal cancer in Spanish population using environmental and genetic factors : results from the MCC-Spain study". Scientific Reports. Vol. 7, art. 43263, (2017). DOI: 10.1038/srep43263 -
Resumen
Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle. -
Project
info:eu-repo/grantAgreement/Instituto de Salud Carlos III-FEDER: Parc de Salut MAR Biobank (MARBiobanc) RD09/0076/00036
info:eu-repo/grantAgreement/FEDER funds-'a way to build Europe' [PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, PI15/00069]
info:eu-repo/grantAgreement/Consejeria de Salud of the Junta de Andalucia [2009-S0143]
Fichero | Tamaño | Formato |
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Risk_model.pdf | 795.5Kb | Ver/ | versión editor |
Fichero | Tamaño | Formato |
| Descripción |
---|---|---|---|---|
Risk_model.pdf | 795.5Kb | Ver/ | versión editor |