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Chiasmata Promote Monopolar Attachment of Sister Chromatids and Their Co-Segregation toward the Proper Pole during Meiosis I
http://hdl.handle.net/10297/5641
http://hdl.handle.net/10297/56411d14342f-0903-4abb-8588-e2bdc739cf8b
名前 / ファイル | ライセンス | アクション |
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110519001.pdf (5.6 MB)
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Item type | 学術雑誌論文 / Journal Article_01(1) | |||||||
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公開日 | 2011-05-19 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Chiasmata Promote Monopolar Attachment of Sister Chromatids and Their Co-Segregation toward the Proper Pole during Meiosis I | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Hirose, Yukinobu
× Hirose, Yukinobu× Suzuki, Ren× Ohba, Tatsunori× Hinohara, Yumi× Matsuhara, Hirotada× Yoshida, Masashi× Itabashi, Yuta× Murakami, Hiroshi× Yamamoto, Ayumu
WEKO
5011
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書誌情報 |
en : PLoS Genetics 巻 7, 号 3, p. e1001329, 発行日 2011-03-10 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | Public Library of Science | |||||||
権利情報 | ||||||||
権利情報 | © 2011 Hirose et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||
NDC | ||||||||
主題Scheme | NDC | |||||||
主題 | 463 | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite spindle poles (bipolar attachment) and their subsequent segregation to the opposite poles during meiosis I. However, the overall function of chiasmata during meiosis is not fully understood. Here, we show that chiasmata also play a crucial role in the attachment of sister chromatids to the same spindle pole and in their co-segregation during meiosis I in fission yeast. Analysis of cells lacking chiasmata and the cohesin protector Sgo1 showed that loss of chiasmata causes frequent bipolar attachment of sister chromatids during anaphase. Furthermore, high time-resolution analysis of centromere dynamics in various types of chiasmate and achiasmate cells, including those lacking the DNA replication checkpoint factor Mrc1 or the meiotic centromere protein Moa1, showed the following three outcomes: (i) during the pre-anaphase stage, the bipolar attachment of sister chromatids occurs irrespective of chiasma formation; (ii) the chiasma contributes to the elimination of the pre-anaphase bipolar attachment; and (iii) when the bipolar attachment remains during anaphase, the chiasmata generate a bias toward the proper pole during poleward chromosome pulling that results in appropriate chromosome segregation. Based on these results, we propose that chiasmata play a pivotal role in the selection of proper attachments and provide a backup mechanism that promotes correct chromosome segregation when improper attachments remain during anaphase I. | |||||||
言語 | en | |||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 15537390 | |||||||
NII書誌ID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA12073492 | |||||||
PubMed番号 | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | PMID | |||||||
関連識別子 | 21423721 | |||||||
出版者DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.1371/journal.pgen.1001329 | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |