Discovery and characterization of novel mechanisms of tumor immune evasion
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Item Details
- title
- Discovery and characterization of novel mechanisms of tumor immune evasion
- author
- Routh, Eric
- abstract
- Background: Understanding how tumors subvert immune destruction is essential to the improvement and future development of immunotherapeutic approaches. Recent studies show that tumors can limit anti-tumor immunity by exploiting transcriptional programs that decrease the abundance of intratumoral immune effector cells. Herein, we sought to identify and characterize gene profiles that distinguish immunologically “cold” and “hot” tumors across diverse tumor types.
- subject
- BMP7
- Cancer
- Tumor immune evasion
- contributor
- Miller, Lance (committee chair)
- Alexander-Miller, Martha (committee member)
- Haas, Karen (committee member)
- Singh, Ravi (committee member)
- Watabe, Kounosuke (committee member)
- date
- 2019-09-05T08:35:31Z (accessioned)
- 2019 (issued)
- degree
- Cancer Biology (discipline)
- embargo
- 2024-08-15 (terms)
- 2024-08-15 (liftdate)
- identifier
- http://hdl.handle.net/10339/94328 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Dissertation