Redmond_2018_Nature.pdf (1.17 MB)
The nature of urgency
thesis
posted on 2022-11-18, 15:40 authored by Elaine Joanne RedmondIntroduction:
Many self-help guides advise patients that spreading fluid intake throughout the day can reduce symptoms of overactive bladder (OAB).A,B However, although animal studies suggest a link between faster filling rates and increased afferent nerve firing, the relationship between filling rate and bladder sensation has not been examined in humans.
The aim of this research is to investigate the effect of bladder volume and rate of bladder filling on bladder sensation and voiding patterns, in the physiological and pathological bladder in a non-clinical, natural filling environment.
Methods:
Forty female volunteers (control group) were recruited by open advertisement. A further 24 female patients with OAB were recruited from the urology outpatients department. Each participant completed a UDI-6, IIQ-7 and 3-day sensation-related bladder diary.
Results:
There was a negative correlation between the rate of bladder filling and the length of intervoiding interval in both groups (p=<0.001). There was a positive correlation between the voided volume and the length of intervoiding interval in both groups (p=<0.001). The proportion of urgent voids in the control group increased with increasing voided volumes (p=<0.001) and bladder filling rates (p=<0.001). The proportion of urgent voids in patients with OAB also increased with increasing voided volumes (p=0.004) and bladder filling rates (p=0.013). On regression analysis the rate of bladder filling was an independent predictor of urgent voids in patients with OAB but not in the control group. Women with OAB were less tolerant of higher bladder filling rates and experienced most grades of bladder sensation at significantly lower voided volumes and filling rates than the control group.
Conclusion:
The rate of bladder filling appears to influence the length of intervoiding interval and sensation associated with each void. Advising patients on strategies to lower their bladder filling rate should help reduce urinary frequency, urgency and urge incontinence.
History
Faculty
- Faculty of Education and Health Sciences
Degree
- Master (Research)
First supervisor
Coffey, Calvin J.Second supervisor
Flood, Hugh D.Note
peer-reviewedLanguage
EnglishDepartment or School
- School of Medicine
Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC