Data on hyper-activation of GPVI signalling inobese patients: towards the identification ofnovel antiplatelet targets in obesity
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Título: | Data on hyper-activation of GPVI signalling inobese patients: towards the identification ofnovel antiplatelet targets in obesity |
Autor/a: | Núñez Barrachina, María Berjano Izquierdo, Irene Hermida Nogueira, Lidia Sueiro, Aurelio M. Guitián Fernández, Esteban Casanueva Freijo, Felipe Farndale, Richard W. Masaaki, Moroi Jung, Stephanie M. Pardo Pérez, María García Alonso, Ángel |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
Data: | 2019 |
Editor: | Elsevier |
Cita bibliográfica: | Barrachina MN, Izquierdo I, Hermida-Nogueira L, et al. Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity. Data in Brief. 2019 Apr;23:103784. DOI: 10.1016/j.dib.2019.103784 |
Resumo: | This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway. |
Versión do editor: | https://doi.org/10.1016/j.dib.2019.103784 |
URI: | http://hdl.handle.net/10347/21321 |
DOI: | 10.1016/j.dib.2019.103784 |
ISSN: | 2352-3409 |
Dereitos: | © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
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