Reversible Control of Protein Corona Formation on Gold Nanoparticles Using Host–Guest Interactions
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Título: | Reversible Control of Protein Corona Formation on Gold Nanoparticles Using Host–Guest Interactions |
Autor/a: | Mosquera Mosquera, Jesús García, Isabel Henriksen-Lacey, Malou Martínez Calvo, Miguel Dhanjani, Mónica Mascareñas Cid, José Luis Liz-Marzán, Luis M. |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | Cell uptake | Metal nanoparticles | Gold | Colloids | Assays | Protein corona | Gold nanoparticles | Host−guest chemistry | Cellular uptake | Photothermal therapy | |
Data: | 2020 |
Editor: | ACS Publications |
Cita bibliográfica: | ACS Nano 2020, 14, 5, 5382–5391 |
Resumo: | When nanoparticles (NPs) are exposed to biological media, proteins are adsorbed, forming a so-called protein corona (PC). This cloud of protein aggregates hampers the targeting and transport capabilities of the NPs, thereby compromising their biomedical applications. Therefore, there is a high interest in the development of technologies that allow control over PC formation, as this would provide a handle to manipulate NPs in biological fluids. We present a strategy that enables the reversible disruption of the PC using external stimuli, thereby allowing a precise regulation of NP cellular uptake. The approach, demonstrated for gold nanoparticles (AuNPs), is based on a biorthogonal, supramolecular host–guest interactions between an anionic dye bound to the AuNP surface and a positively charged macromolecular cage. This supramolecular complex effectively behaves as a zwitterionic NP ligand, which is able not only to prevent PC formation but also to disrupt a previously formed hard corona. With this supramolecular stimulus, the cellular internalization of AuNPs can be enhanced by up to 30-fold in some cases, and even NP cellular uptake in phagocytic cells can be regulated. Additionally, we demonstrate that the conditional cell uptake of purposely designed gold nanorods can be used to selectively enhance photothermal cell death |
Versión do editor: | https://doi.org/10.1021/acsnano.9b08752 |
URI: | http://hdl.handle.net/10347/22786 |
DOI: | 10.1021/acsnano.9b08752 |
ISSN: | 1936-0851 |
E-ISSN: | 1936-086X |
Dereitos: | Copyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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Copyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes
Copyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes