Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/23836
Ficheiros no ítem
Metadatos do ítem
Título: | Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus |
Autor/a: | Heredia, Margarita Rodríguez, Natalia Sánchez Robledo, Virginia Criado, José María Fuente, Antonio de la Devesa Múgica, Jesús Devesa Peleteiro, Pablo Sánchez Riolobos, Adelaida |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Fisioloxía |
Palabras chave: | Growth hormone | Traumatic brain injury | Neural plasticity | Neurogenesis | Actin | Nestin | Striatum | Thalamus | |
Data: | 2019 |
Editor: | MDPI |
Cita bibliográfica: | Heredia, M.; Rodríguez, N.; Sánchez Robledo, V.; Criado, J.M.; de la Fuente, A.; Devesa, J.; Devesa, P.; Sánchez Riolobos, A. Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus. Int. J. Mol. Sci. 2019, 20, 5770 |
Resumo: | Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (n = 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery |
Versión do editor: | https://doi.org/10.3390/ijms20225770 |
URI: | http://hdl.handle.net/10347/23836 |
DOI: | 10.3390/ijms20225770 |
E-ISSN: | 1422-0067 |
Dereitos: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
Coleccións
-
- FIS-Artigos [114]
O ítem ten asociados os seguintes ficheiros de licenza: