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Título
Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
Autor(es)
Materia
Chronic Lymphocytic Leukemia
Next-generation sequencing
Clonal evolution
Immunogenetics
CLL prognosis
Fecha de publicación
2017-07
Citación
Rodríguez-Vicente A. E., Bikos V., Hernández-Sánchez M., Malcikova J., Hernández-Rivas J., Pospisilova S (2017). Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons. Oncotarget, vol. 8 (41), pp. 71234-71248. https://doi.org/10.18632/oncotarget.19525
Resumen
[EN] The rapid progress in next-generation sequencing technologies has significantly
contributed to our knowledge of the genetic events associated with the development,
progression and treatment resistance of chronic lymphocytic leukemia patients.
Together with the discovery of new driver mutations, next-generation sequencing
has revealed an immense degree of both intra- and inter-tumor heterogeneity and
enabled us to describe marked clonal evolution. Advances in immunogenetics may be
implemented to detect minimal residual disease more sensitively and to track clonal
B cell populations, their dynamics and molecular characteristics. The interpretation
of these aspects is indispensable to thoroughly examine the genetic background of
chronic lymphocytic leukemia. We review and discuss the recent results provided by
the different next-generation sequencing techniques used in studying the chronic
lymphocytic leukemia genome, as well as future perspectives in the methodologies
and applications.
URI
ISSN
1949-2553
DOI
10.18632/oncotarget.19525
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