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Reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer
Cited 19 time in
Web of Science
Cited 17 time in Scopus
- Authors
- Issue Date
- 2005-10
- Publisher
- 대한의학회
- Citation
- Journal of Korean Medical Science, Vol.20 No.5, pp.806-810
- Abstract
- To evaluate the toxicity and efficacy of a reduced dose intensity (mini-) FOLFOX-4 regimen as a first-line palliative chemotherapy in elderly patients (>= 70 yr of age) with advanced colorectal cancer, data from prospective databases at Seoul National University Bundang Hospital and Seoul Municipal Boramae Hospital were analyzed. A total of 20 patients were enrolled between January 2001 and August 2004, and were treated with oxaliplatin 65 mg/m(2) on day 1, and with 2-hr infusions of leucovorin 150 mg/m(2) followed by a 5-FU bolus (300 mg/m(2)) and 22-hr continuous infusions (450 mg/m(2)) for 2 consecutive days every 2 weeks until progression, unacceptable toxicity or patient refusal. Sixteen patients were evaluable for response with an overall response rate of 43.8%. Median progression-free survival was 4.8 months (95% CI: 3.0-6.7) and overall survival was 13.5 months (95% Cl: 11.1-16.0). The main side effects were anemia and neutropenia, which were observed in 20.8% and 117.7%, respectively, of the total cycles administered. There were no grade 4 toxicities an only one patient suffered from febrile neutropenia. No grade 3 toxicities occurred except for anemia (5.2%) and vomiting (1.0%). In conclusion, the mini-FOLFOX-4 regimen was found to be well tolerated with acceptable toxicity, and to provide a benefit for elderly patients with colorectal cancer.
- ISSN
- 1011-8934
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