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Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study
Cited 43 time in
Web of Science
Cited 49 time in Scopus
- Authors
- Issue Date
- 2006-07-04
- Citation
- Am J Geriatr Psychiatry. 2006 Jul;14(7):625-8.
- Keywords
- Aged ; Alzheimer Disease/*physiopathology/*radionuclide imaging ; Depressive Disorder, Major/*physiopathology/*radionuclide imaging ; Female ; Fluorodeoxyglucose F18/*diagnostic use/*pharmacokinetics ; Frontal Lobe/*metabolism/*physiopathology ; Humans ; Male ; Radiopharmaceuticals/*diagnostic use/*pharmacokinetics ; Positron-Emission Tomography
- Abstract
- OBJECTIVE: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). METHOD: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. RESULTS: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. CONCLUSIONS: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
- ISSN
- 1064-7481 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816017
https://hdl.handle.net/10371/29693
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