교체이중망법에 의한 Lexotan의 임상적연구

Abstract

A double blined crossover study of Lexotan was carried out in 40 patients who had been suffered from anxiety neurosis, obsessive-compulsive neurosis, pbobia and psychosomatic disorder. The results were as follows: 1. It was found that Lexotan was far more effective than placebo in the improving the neurotic symptoms. 2. There was no difference between group A (Lexotan gmg/day) and group B (Lexotan 18mg/ day). 3. No difference was found between control and placebo. 4. There was a significant difference between placebo and Lexotan. 5. The slight effectiveness of placebo in L-P group compared with placebo in P-L group was due to an improvement by Lexotan that was given previously, however there was no statistic difference between them. 6. There was no difference in improvement among diagnostic group by Lexotan. 7. Tbe incidence of side effect was relatively low (20%) and most of the side effects(anxiety, agitation, ataxia, drowsiness and dry month) were occured within 48 hours. 8. We had found no abstinence syndromes nor habituation signs in the study.