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Hair growth promoting effects of adipose tissue-derived stem cells
Cited 66 time in
Web of Science
Cited 70 time in Scopus
- Authors
- Issue Date
- 2010-02
- Publisher
- ELSEVIER IRELAND LTD
- Citation
- JOURNAL OF DERMATOLOGICAL SCIENCE; Vol.57 2; 134-137
- Abstract
- Adipose tissue-derived stem cells (ADSCs) can display multilineage
plasticity and share similar characteristics with bone
marrow-derived mesenchymal stem cells [1]. Moreover, ADSCs
have various cytokine-secreting properties and beneficial paracrine
effects on surrounding cells or tissues [2]. Recently, paracrine
function is considered one of the most important therapeutic
benefits of therapy using mesenchymal stem cells [3,4].
Regarding hair biology, several reports have demonstrated that
growth factors from the surroundings stimulate hair growth in ex
vivo and animal models [5,6].We have identified secretory factors
derived from ADSCs by ELISA and proteomics previously, including
IGF binding protein precursors, PDGF, KGF, HGF, VEGF, and
fibronectin [7,8]. These factors are well-documented to be related
to hair growth stimulation [6]. To determine whether these
paracrine effects of ADSCs can promote hair growth, we
investigated the effects of ADSCs on hair.
- ISSN
- 0923-1811
- Language
- English
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