Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries
Date
2019Author
Drane, Aimee L.
Howatson, Glyn
Atencia, Rebeca
Cooper, Stephen-Marc
Rodriques, Pablo
Metadata
Show full item recordAbstract
OBJECTIVE
To comprehensively characterize cardiac structure and function, from infancy to adulthood, in male and female wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries.
ANIMALS
290 wild-born captive chimpanzees.
PROCEDURES
Physical and echocardiographic examinations were performed on anesthetized chimpanzees in 3 sanctuaries in Africa between October 2013 and May 2017. Results were evaluated across age groups and between sexes, and potential differences were assessed with multiple 1-way independent Kruskal-Wallis tests.
RESULTS
Results indicated that left ventricular diastolic and systolic function declined at a younger age in males than in females. Although differences in right ventricular diastolic function were not identified among age groups, right ventricular systolic function was lower in adult chimpanzees (> 12 years old), compared with subadult (8 to 12 years old) and juvenile (5 to 7 years old) chimpanzees. In addition, male subadult and adult chimpanzees had larger cardiac wall dimensions and chamber volumes than did their female counterparts.
CONCLUSIONS AND CLINICAL RELEVANCE
Results of the present study provided useful reference intervals for cardiac structure and function in captive chimpanzees categorized on the basis of age and sex; however, further research is warranted to examine isolated and combined impacts of blood pressure, age, body weight, and anesthetic agents on cardiac structure and function in chimpanzees.
URI
http://hdl.handle.net/10394/32943https://avmajournals.avma.org/doi/pdf/10.2460/ajvr.80.6.547
https://doi.org/10.2460/ajvr.80.6.547