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Title: | Association between METS-IR and prediabetes or type 2 diabetes mellitus among elderly subjects in China : a large-scale population-based study | Authors: | Cheng, H Yu, X Li, YT Jia, Z Wang, JJ Xie, YJ Hernandez, J Wang, HHX Wu, HF |
Issue Date: | Jan-2023 | Source: | International journal of environmental research and public health, Jan. 2023, v. 20, no. 2, 1053 | Abstract: | The metabolic score for insulin resistance (METS-IR) was recently proposed as a non-insulin-based, novel index for assessing insulin resistance (IR) in the Western population. However, evidence for the link between METS-IR and prediabetes or type 2 diabetes mellitus (T2DM) among the elderly Chinese population was still limited. We aimed to investigate the associations between METS-IR and prediabetes or T2DM based on large-scale, cross-sectional, routine physical examination data. In a total of 18,112 primary care service users, an increased METS-IR was independently associated with a higher prevalence of prediabetes (adjusted odds ratio [aOR] = 1.457, 95% confidence interval [CI]: 1.343 to 1.581, p < 0.001) and T2DM (aOR = 1.804, 95%CI: 1.720 to 1.891, p < 0.001), respectively. The aOR for prediabetes in subjects with the highest quartile of METS-IR was 3.060-fold higher than that in those with the lowest quartile of METS-IR. The aOR for T2DM in subjects with the highest quartile of METS-IR was 6.226-fold higher than that in those with the lowest quartile of METS-IR. Consistent results were obtained in subgroup analyses. Our results suggested that METS-IR was significantly associated with both prediabetes and T2DM. The monitoring of METS-IR may add value to early identification of individuals at risk for glucose metabolism disorders in primary care. | Keywords: | Cross-sectional study Insulin resistance METS-IR Prediabetes T2DM |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | International journal of environmental research and public health | ISSN: | 1661-7827 | EISSN: | 1660-4601 | DOI: | 10.3390/ijerph20021053 | Rights: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). The following publication Cheng H, Yu X, Li Y-T, Jia Z, Wang J-J, Xie Y-J, Hernandez J, Wang HHX, Wu H-F. Association between METS-IR and Prediabetes or Type 2 Diabetes Mellitus among Elderly Subjects in China: A Large-Scale Population-Based Study. International Journal of Environmental Research and Public Health. 2023; 20(2):1053 is available at https://doi.org/10.3390/ijerph20021053. |
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