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http://hdl.handle.net/10397/92233
Title: | Preclinical mouse models of hepatocellular carcinoma : an overview and update | Authors: | Gu, CY Lee, TKW |
Issue Date: | 15-Mar-2022 | Source: | Experimental cell research, 15 Mar. 2022, v. 412, no. 2, 113042 | Abstract: | Hepatocellular carcinoma (HCC) is by far the most common histological subtype of primary liver cancer. HCC often originates from chronic liver injuries and inflammation, subsequently leading to fibrosis and cirrhosis. Preclinical animal models, especially mice, are viewed as valuable and reliable tools for investigating the molecular processes involved in hepatocarcinogenesis and facilitating the evaluations of the efficacy of novel therapies for HCC. A wide range of mouse models of HCC has been established using various approaches including chemotoxic agents, genetic modifications, special diet administration, and tumor cells transplantation. Choosing a suitable model to represent certain genetic and physiological features of human HCC seems to be crucial. Here, we review the current preclinical mouse models that are frequently used to study HCC. | Keywords: | Hepatocellular carcinoma Liver cancer Mouse models Preclinical models |
Publisher: | Academic Press | Journal: | Experimental cell research | ISSN: | 0014-4827 | EISSN: | 1090-2422 | DOI: | 10.1016/j.yexcr.2022.113042 | Rights: | © 2022 Elsevier Inc. All rights reserved. © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The following publication Gu, C. Y., & Lee, T. K. W. (2022). Preclinical mouse models of hepatocellular carcinoma: An overview and update. Experimental Cell Research, 412(2), 113042 is available at https://dx.doi.org/10.1016/j.yexcr.2022.113042. |
Appears in Collections: | Journal/Magazine Article |
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