Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10400.7/145
Título: | A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration |
Autor: | Quirk, MC Sosulski, DL Feierstein, CE Uchida, N Mainen, ZF |
Data: | 2009 |
Editora: | Cold Spring Harbor |
Citação: | Quirk, Michael C., Sosulski, Dara L., Feierstein, Claudia E., Naoshige, U., Mainen, Zachary F. (2009). “A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration”. Frontiers in Systems Neuroscience. 3: 1-13 |
Resumo: | Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states. |
URI: | http://hdl.handle.net/10400.7/145 |
ISSN: | 1662-5137 |
Aparece nas colecções: | SN - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Fronties in systems neuroscience.pdf | 1,67 MB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.