Miopatia atípica: análise de casos clínicos
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2011
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A Miopatia atípica é uma doença emergente em alguns países europeus, que afecta cavalos de pasto, caracterizada por fraquez súbita, decúbito prolongado e degeneração muscular aguda. Tem-se verificado recentemente um aumento do número de surtos, incluindo em países em que a doença nunca fora diagnosticada anteriormente, o que justifica o presente estudo, que tem como objectivo a contribuição para a descrição do perfil epidemológico da MA, com base na descrição de dados geográficos, demográficos e clínicos de casos confirmados e suspeitos de MA, observados num Hospital Equino de referência, na Bélgica, durante o Outono de 2010.
Foram incluídos na análise retrospectiva da série de casos clínicos estudados tanto a identificação fenotípica de cada indivíduo, assim como as respectivas práticas de maneio, incluindo condições de pastoreio, história clínica e achados bioquímicos e, sempre que possível, histopatológicos.
Os sinais clínicos ocorreram em condições climáticas desfavoráveis. Os sintomas mais frequentes incluíram fraqueza e recusa em mover-se. As concentrações de creatinina quinase, CK, variaram entre 20360 UI/L a 213350 UI/L nos casos confirmados, CC e casos de elevada probabilidade, CEP para miopatia atípica, MA.
A associação de MA com as condições climáticas sugere que o maneio das pastagens é de extrema importância na prevenção da condição.
The atypical myopathy (AM) is a disease which is emerging in some European countries that affects grazing horses and is characterized by a sudden weakness as well as a prolonged state of lying down and acute muscular degeneration. Recently, it has been verified that the number of cases is increasing, including in countries in which the disease had not been diagnosed before. This justifies the present study whose goal is to contribute for the epidemiologic profile of AM based on the description of geographic, demographic and clinical data of confirmed and suspected cases of AM, observed at the referenced Equine Hospital, in Belgium, during the fall of 2010. In the retrospective analysis of the cases included in this study, the phenotypic identification of each individual as well as its handling practices, including the grazing conditions, clinical history, biochemical findings and, when possible, histopathological findings have been included. In this study, the most frequent clinical signs include weakness and refuse to move. The concentration of creatinine Kinase vary between 20360 UI/L a 213350 UI/L in confirmed cases, CC and high probability cases, CEP for atypical myopathy, MA. The association of MA with climatic conditions suggest that the management of pastures is of primary importance to prevent this condition.
The atypical myopathy (AM) is a disease which is emerging in some European countries that affects grazing horses and is characterized by a sudden weakness as well as a prolonged state of lying down and acute muscular degeneration. Recently, it has been verified that the number of cases is increasing, including in countries in which the disease had not been diagnosed before. This justifies the present study whose goal is to contribute for the epidemiologic profile of AM based on the description of geographic, demographic and clinical data of confirmed and suspected cases of AM, observed at the referenced Equine Hospital, in Belgium, during the fall of 2010. In the retrospective analysis of the cases included in this study, the phenotypic identification of each individual as well as its handling practices, including the grazing conditions, clinical history, biochemical findings and, when possible, histopathological findings have been included. In this study, the most frequent clinical signs include weakness and refuse to move. The concentration of creatinine Kinase vary between 20360 UI/L a 213350 UI/L in confirmed cases, CC and high probability cases, CEP for atypical myopathy, MA. The association of MA with climatic conditions suggest that the management of pastures is of primary importance to prevent this condition.
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Orientação: Hélène Amory ; co-orientação: Manuel Pequito
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MEDICINA VETERINÁRIA, CRIATININA QUINASE, PASTAGENS, MIOPATIA ATÍPICA, VETERINARY MEDICINE, ATYPICAL MYOPHATY, CREATININE KINASE, PASTURES, MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, VETERINÁRIA