The term“multicomponent solid dispersion”is widely used in recent literature to describe solid formulationsconsisting of a special excipient's mixture and active moleculesfinely dispersed. However, this term has not yetbeen defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a newgeneration of solid dispersions capable to improve both formulation issues and the therapeutic effect of thefinaldosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, thisreview describes thefield of solid dispersions as well as the formulation strategies available for their production.In particular, the review highlights the use of the spray-drying technique and the benefits provided by thismethod in the manufacturing of multicomponent solid dispersion.

De Mohac, L.M., Raimi-Abraham, B., Caruana, R., Gaetano, G., Licciardi, M. (2020). Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 57, 1-6 [10.1016/j.jddst.2020.101750].

Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying

De Mohac, Laura Modica;Caruana, Roberto;Gaetano, Giammona;Licciardi, Mariano
2020-01-01

Abstract

The term“multicomponent solid dispersion”is widely used in recent literature to describe solid formulationsconsisting of a special excipient's mixture and active moleculesfinely dispersed. However, this term has not yetbeen defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a newgeneration of solid dispersions capable to improve both formulation issues and the therapeutic effect of thefinaldosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, thisreview describes thefield of solid dispersions as well as the formulation strategies available for their production.In particular, the review highlights the use of the spray-drying technique and the benefits provided by thismethod in the manufacturing of multicomponent solid dispersion.
2020
De Mohac, L.M., Raimi-Abraham, B., Caruana, R., Gaetano, G., Licciardi, M. (2020). Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 57, 1-6 [10.1016/j.jddst.2020.101750].
File in questo prodotto:
File Dimensione Formato  
JDDST 2020 review spray drying.pdf

Solo gestori archvio

Descrizione: Articolo principale
Tipologia: Versione Editoriale
Dimensione 253.53 kB
Formato Adobe PDF
253.53 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
review_Spray_New_draft_Laura_Feb2020_JDDST.pdf

accesso aperto

Tipologia: Pre-print
Dimensione 293.3 kB
Formato Adobe PDF
293.3 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/408598
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 22
social impact