Evaluation of Nanofiber PLA Scaffolds Using Dry- and Wet-Electrospinning Methods

Ghorbani, S; Razavi Bazaz, S; Ebrahimi Warkiani, M; Soleimani, M; Abouei Mehrizi, A

Evaluation of Nanofiber PLA Scaffolds Using Dry- and Wet-Electrospinning Methods

Ghorbani, S Razavi Bazaz, S

Ebrahimi Warkiani, M

Soleimani, M Abouei Mehrizi, A

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Publication Type:: Conference Proceeding
Citation:: 2017 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 2018
Issue Date:: 2018-08-08

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Field	Value	Language
dc.contributor.author	Ghorbani, S	en_US
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361	en_US
dc.contributor.author	Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944	en_US
dc.contributor.author	Soleimani, M	en_US
dc.contributor.author	Abouei Mehrizi, A	en_US
dc.date.available	2020-08-09T19:03:14Z
dc.date.issued	2018-08-08	en_US
dc.identifier.citation	2017 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 2018	en_US
dc.identifier.isbn	9781538636091	en_US
dc.identifier.uri	http://hdl.handle.net/10453/132605
dc.description.abstract	© 2017 IEEE. Investigating the fabrication of a favorable scaffold is a continuing sconcern and an essential step within tissue engineering. An ideal scaffold should mimic the structure of extracellular matrix (ECM) which has considerable impacts on its function. To meet this demands, in this study, three-dimensional scaffolds by polylactic acid (PLA) polymer 10%, 13%, 15%, 17% and 20% (w/v) with a novel architecture produced by a wet-electrospinning process have been fabricated and compared with dry-electrospun scaffolds that have been developed for tissue engineering applications. In the wet-electrospinning method, an aqueous solution of sodium hydroxide (NaOH) (pH∼13) has been used as the coagulation bath instead of the aluminum collector which is used in the dry method. Comparing with usual nanofiber non-woven PLA fabric prepared by a conventional electrospinning method, wet-electrospun spongiform PLA nanofiber scaffolds have low apparent density and high porosity. The porosity of the scaffolds has been examined in this two methods and their mechanical properties as well as their morphology are investigated. All in all, it is shown that the novel nanofiber fabrication system would be amazingly useful for the structure control of the nanofiber fabric.	en_US
dc.relation.ispartof	2017 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017	en_US
dc.relation.isbasedon	10.1109/ICBME.2017.8430270	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Evaluation of Nanofiber PLA Scaffolds Using Dry- and Wet-Electrospinning Methods	en_US
dc.type	Conference Proceeding
utslib.for	0912 Materials Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
pubs.publication-status	Published	en_US

Abstract:

© 2017 IEEE. Investigating the fabrication of a favorable scaffold is a continuing sconcern and an essential step within tissue engineering. An ideal scaffold should mimic the structure of extracellular matrix (ECM) which has considerable impacts on its function. To meet this demands, in this study, three-dimensional scaffolds by polylactic acid (PLA) polymer 10%, 13%, 15%, 17% and 20% (w/v) with a novel architecture produced by a wet-electrospinning process have been fabricated and compared with dry-electrospun scaffolds that have been developed for tissue engineering applications. In the wet-electrospinning method, an aqueous solution of sodium hydroxide (NaOH) (pH∼13) has been used as the coagulation bath instead of the aluminum collector which is used in the dry method. Comparing with usual nanofiber non-woven PLA fabric prepared by a conventional electrospinning method, wet-electrospun spongiform PLA nanofiber scaffolds have low apparent density and high porosity. The porosity of the scaffolds has been examined in this two methods and their mechanical properties as well as their morphology are investigated. All in all, it is shown that the novel nanofiber fabrication system would be amazingly useful for the structure control of the nanofiber fabric.

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http://hdl.handle.net/10453/132605