Neurological effects of iron supplementation in infancy: finding the balance between health and harm in iron-replete infants

Hare, DJ; Cardoso, BR; Szymlek-Gay, EA; Biggs, BA

Neurological effects of iron supplementation in infancy: finding the balance between health and harm in iron-replete infants

Hare, DJ

Cardoso, BR Szymlek-Gay, EA Biggs, BA

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Publication Type:: Journal Article
Citation:: The Lancet Child and Adolescent Health, 2018, 2 (2), pp. 144 - ?
Issue Date:: 2018-02-01

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Field	Value	Language
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Cardoso, BR	en_US
dc.contributor.author	Szymlek-Gay, EA	en_US
dc.contributor.author	Biggs, BA	en_US
dc.date.available	2017-10-13	en_US
dc.date.issued	2018-02-01	en_US
dc.identifier.citation	The Lancet Child and Adolescent Health, 2018, 2 (2), pp. 144 - ?	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133370
dc.description.abstract	© 2018 Elsevier Ltd Iron mediates many biochemical processes in neural networks that proliferate during brain development. Insufficient iron causes irreversible neurodevelopmental deficits, and most high-income countries recommend that infants older than 4–6 months receive additional iron via food fortification or supplementation to prevent iron-deficiency anaemia. Now that the prevalence of iron-deficiency anaemia in children has decreased to less than 10% in most developed countries, concerns that the recommended intakes far exceed those required to prevent iron-deficiency anaemia have been raised, and emerging evidence suggests that iron overexposure could be linked to adverse outcomes later in life. In this Viewpoint, we discuss the importance of iron for neurodevelopment, investigate the biochemical markers used to assess iron stores, summarise the disparity in public health policies among high-income countries, and discuss the potential association between iron overexposure and adverse neurological outcomes later in life. We present a case for new studies to establish the optimal amount of iron that both prevents deficiency and reduces the potential risk of long-term negative health outcomes.	en_US
dc.relation.ispartof	The Lancet Child and Adolescent Health	en_US
dc.relation.isbasedon	10.1016/S2352-4642(17)30159-1	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Anemia, Iron-Deficiency	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	Dietary Supplements	en_US
dc.subject.mesh	Food, Fortified	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Child, Preschool	en_US
dc.subject.mesh	Infant	en_US
dc.title	Neurological effects of iron supplementation in infancy: finding the balance between health and harm in iron-replete infants	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	2	en_US

Abstract:

© 2018 Elsevier Ltd Iron mediates many biochemical processes in neural networks that proliferate during brain development. Insufficient iron causes irreversible neurodevelopmental deficits, and most high-income countries recommend that infants older than 4–6 months receive additional iron via food fortification or supplementation to prevent iron-deficiency anaemia. Now that the prevalence of iron-deficiency anaemia in children has decreased to less than 10% in most developed countries, concerns that the recommended intakes far exceed those required to prevent iron-deficiency anaemia have been raised, and emerging evidence suggests that iron overexposure could be linked to adverse outcomes later in life. In this Viewpoint, we discuss the importance of iron for neurodevelopment, investigate the biochemical markers used to assess iron stores, summarise the disparity in public health policies among high-income countries, and discuss the potential association between iron overexposure and adverse neurological outcomes later in life. We present a case for new studies to establish the optimal amount of iron that both prevents deficiency and reduces the potential risk of long-term negative health outcomes.

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http://hdl.handle.net/10453/133370