Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cells

Xu, X; Roseblade, A; Rawling, T; Ung, AT

Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cells

Xu, X Roseblade, A

Rawling, T

Ung, AT

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Publisher:: Royal Society of Chemistry (RSC)
Publication Type:: Journal Article
Citation:: RSC Medicinal Chemistry, 2020, 11, (1), pp. 118-124
Issue Date:: 2020

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Field	Value	Language
dc.contributor.author	Xu, X
dc.contributor.author	Roseblade, A https://orcid.org/0000-0002-2368-9336
dc.contributor.author	Rawling, T https://orcid.org/0000-0002-6624-6586
dc.contributor.author	Ung, AT
dc.date.accessioned	2020-10-23T02:53:20Z
dc.date.available	2020-10-23T02:53:20Z
dc.date.issued	2020
dc.identifier.citation	RSC Medicinal Chemistry, 2020, 11, (1), pp. 118-124
dc.identifier.issn	2632-8682
dc.identifier.issn	2632-8682
dc.identifier.uri	http://hdl.handle.net/10453/143492
dc.description.abstract	<p>Tricyclic amides were successfully synthesised from β-caryophyllene <italic>via</italic> the Ritter reaction. Amides <bold>3c</bold> and <bold>6b</bold> inhibited proliferation of MDA-MB-231 cells. Compound <bold>6b</bold> inhibited cell cycle progression and induced predominantly apoptotic cell death.</p>
dc.language	en
dc.publisher	Royal Society of Chemistry (RSC)
dc.relation.ispartof	RSC Medicinal Chemistry
dc.relation.isbasedon	10.1039/c9md00237e
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cells
dc.type	Journal Article
utslib.citation.volume	11
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-23T02:52:45Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	11
utslib.citation.issue	1

Abstract:

Tricyclic amides were successfully synthesised from β-caryophyllene via the Ritter reaction. Amides 3c and 6b inhibited proliferation of MDA-MB-231 cells. Compound 6b inhibited cell cycle progression and induced predominantly apoptotic cell death.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/143492