The controlled release of simvastatin from biomimetic macrospheres

Chou, J; Ito, T; Otsuka, M; Ben-Nissan, B; Milthorpe, B

The controlled release of simvastatin from biomimetic macrospheres

Chou, J

Ito, T Otsuka, M Ben-Nissan, B Milthorpe, B

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Publication Type:: Journal Article
Citation:: Key Engineering Materials, 2013, 529-530 (1), pp. 461 - 464
Issue Date:: 2013-01-01

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Field	Value	Language
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Ito, T	en_US
dc.contributor.author	Otsuka, M	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586	en_US
dc.date.issued	2013-01-01	en_US
dc.identifier.citation	Key Engineering Materials, 2013, 529-530 (1), pp. 461 - 464	en_US
dc.identifier.isbn	9783037855171	en_US
dc.identifier.issn	1013-9826	en_US
dc.identifier.uri	http://hdl.handle.net/10453/27987
dc.description.abstract	Simvastatin has been shown to succesfully stimulate bone regeneration and attention has being focussed on developing appropriate delivery carriers for its release. The challenge of deliverying therapeutic concentration of pharmaceutical compunds has being the centre of focus in drug delivery developments. This study examines the in-vivo effects of simvastatin released from β-TCP macrospheres derived from coral exoxskeletons. The results indicates that the controlled release of simvastatin can promote bone formation comparable with direct injection. Furthermore the results showed that the release of simvastatin delivery rates can be controlled by additional coating of an apatite coating. Analysis by CT scans, SEM, amount of new bone formed and mechanical strength tests, showed that by controlling the release of simvastatin bone formation can be stimulated to a therapeutic level. © (2013) Trans Tech Publications, Switzerland.	en_US
dc.relation.ispartof	Key Engineering Materials	en_US
dc.relation.isbasedon	10.4028/www.scientific.net/KEM.529-530.461	en_US
dc.subject.classification	Materials	en_US
dc.title	The controlled release of simvastatin from biomimetic macrospheres	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	529-530	en_US
utslib.for	0912 Materials Engineering	en_US
utslib.for	09 Engineering	en_US
dc.location.activity	Fukuoka, Japan	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	529-530	en_US

Abstract:

Simvastatin has been shown to succesfully stimulate bone regeneration and attention has being focussed on developing appropriate delivery carriers for its release. The challenge of deliverying therapeutic concentration of pharmaceutical compunds has being the centre of focus in drug delivery developments. This study examines the in-vivo effects of simvastatin released from β-TCP macrospheres derived from coral exoxskeletons. The results indicates that the controlled release of simvastatin can promote bone formation comparable with direct injection. Furthermore the results showed that the release of simvastatin delivery rates can be controlled by additional coating of an apatite coating. Analysis by CT scans, SEM, amount of new bone formed and mechanical strength tests, showed that by controlling the release of simvastatin bone formation can be stimulated to a therapeutic level. © (2013) Trans Tech Publications, Switzerland.

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http://hdl.handle.net/10453/27987