Small RNAs derived from the 5′ end of tRNAs can inhibit protein translation in human cells

Sobala, A; Hutvagner, G

Small RNAs derived from the 5′ end of tRNAs can inhibit protein translation in human cells

Sobala, A Hutvagner, G

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Publication Type:: Journal Article
Citation:: RNA Biology, 2013, 10 (4), pp. 553 - 563
Issue Date:: 2013-01-01

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Field	Value	Language
dc.contributor.author	Sobala, A	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.date.issued	2013-01-01	en_US
dc.identifier.citation	RNA Biology, 2013, 10 (4), pp. 553 - 563	en_US
dc.identifier.issn	1547-6286	en_US
dc.identifier.uri	http://hdl.handle.net/10453/29543
dc.description.abstract	Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5′ and 3′ termini. To date, the function of these tRNA fragments (tRFs) derived from the 5′ end of tRNAs has not been investigated in depth. We present evidence that conserved residues in tRNAs, present in all 5′ tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5′ tRFs in a new mechanism of gene regulation by small RNAs in human cells. © 2013 Landes Bioscience.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP130103027
dc.relation.ispartof	RNA Biology	en_US
dc.relation.isbasedon	10.4161/rna.24285	en_US
dc.subject.classification	Developmental Biology	en_US
dc.subject.mesh	Hela Cells	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	RNA, Messenger	en_US
dc.subject.mesh	RNA, Transfer	en_US
dc.subject.mesh	Transfection	en_US
dc.subject.mesh	Protein Biosynthesis	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	Genes, Reporter	en_US
dc.subject.mesh	RNA, Small Untranslated	en_US
dc.subject.mesh	Argonaute Proteins	en_US
dc.subject.mesh	HeLa Cells	en_US
dc.title	Small RNAs derived from the 5′ end of tRNAs can inhibit protein translation in human cells	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	10	en_US
utslib.for	0604 Genetics	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5′ and 3′ termini. To date, the function of these tRNA fragments (tRFs) derived from the 5′ end of tRNAs has not been investigated in depth. We present evidence that conserved residues in tRNAs, present in all 5′ tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5′ tRFs in a new mechanism of gene regulation by small RNAs in human cells. © 2013 Landes Bioscience.

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http://hdl.handle.net/10453/29543