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Arsenic metabolites in dermal cellular milieu: Molecular analysis
http://hdl.handle.net/10458/6893
http://hdl.handle.net/10458/6893cee07921-11d6-4e8d-b9be-609857231960
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (1.1 MB)
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| Item type | その他 / Others(1) | |||||||||||||
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| 公開日 | 2020-06-22 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Arsenic metabolites in dermal cellular milieu: Molecular analysis | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Arsenic, Cell health, Dermal lesions, Signal transduction | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||||||||||
| 資源タイプ | other | |||||||||||||
| 著者 |
マドゥエスタ, ハリーシャクマール
× マドゥエスタ, ハリーシャクマール
WEKO
7810
× Madhyastha, Radha× 中島, 融一× 丸山, 眞杉 |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Contamination of drinking water by arsenic metabolites, which can occur naturally or due to human activities such as mining and industrialization, is an important public health issue in south Asia. More than 200 million are exposed to arsenic through drinking water. Chronic exposure to this metalloid has been associated with onset of many diseases, including cancer. There are 4 major molecular mechanisms through which arsenic disturbs cell health. They are （1） Arsenic contaminated water disturbs the gastric mucosal barrier thereby altering the cell stress hemostasis （2） Tt directly or indirectly interacts with energy synthesis pathway and induces cellular ROS generation （3） Tt inhibits the repair machinery （4） Finally, arsenic induces DNA abnormality. Understanding the molecular mechanisms of arsenic exposure and its subsequent health effects at cellular level will support efforts to reduce the worldwide health burden and encourage the development of strategies for managing arsenic-related diseases in the era of personalized medicine. | |||||||||||||
| 言語 | en | |||||||||||||
| 書誌情報 |
en : 5th International Arsenic Symposium in MIYAZAKI 2018 p. 62-64, 発行日 2018-06 |
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| 出版者 | ||||||||||||||
| 出版者 | University of Miyazaki, IRISH | |||||||||||||
| 言語 | en | |||||||||||||
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| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
